REDS4VEDS Day Date in the current year: May 15, 2026

Ehlers-Danlos syndrome (EDS) is an umbrella term for at least 13 genetic connective tissue disorders caused by mutations in 19 different genes. These disorders are grouped together because they share similar symptoms, such as overly flexible joints, stretchy skin, and abnormal scar tissue formation.

One type of EDS is vascular EDS formerly known as Sack-Barabas syndrome. Vascular EDS is caused by mutations in the COL3A1 gene, which encodes type III collagen. This important structural protein is present in blood vessels and hollow organs, such as the intestines and uterus. Patients with vascular EDS have fragile blood vessels and extremely thin, fragile skin that bruises easily and makes small blood vessels visible on the legs and upper chest. Joint hypermobility is present but less pronounced than in other types of EDS, primarily affecting the joints in the fingers and toes.

Vascular EDS is one of the most dangerous subtypes of Ehlers-Danlos syndrome because it carries a high risk of spontaneous blood vessel and organ rupture. Aortic rupture is the main cause of death in patients. About 20-30% of affected individuals experience intestinal rupture, and women are at risk of uterine rupture during pregnancy. Patients with this condition are also prone to the early development of varicose veins, gum problems, spontaneous lung collapse (pneumothorax), premature skin aging on the hands and feet, and delayed wound healing.

There is no cure or specific treatment for vascular EDS. Management involves being aware of the condition, eliminating potential complications, and undergoing regular medical checkups. Patients with vascular EDS should avoid invasive medical procedures, strenuous physical activities, smoking or vaping, and playing brass and woodwind instruments. They should also eat a balanced diet with enough fiber to prevent constipation, as constipation can lead to bowel rupture.

REDS4VEDS Day is owned and hosted by the UK charity Annabelle’s Challenge. The charity was founded by Jared and Sarah Griffin, whose daughter, Annabelle, was diagnosed with vascular EDS at the age of three. The Griffins founded the charity in 2013 to connect with and support other families facing this rare diagnosis. Two years later, Jared co-founded REDS4VEDS Day with Evie Evans (Ireland) to educate the public about vascular EDS and to raise funds to support affected families and further research into the condition.

The best way to participate in REDS4VEDS Day is to donate to or organize a fundraiser for the global REDS4VEDS campaign to support patients with vascular EDS and their families. If you can’t donate, that’s okay! You can still show your support and raise awareness of the condition by wearing red, taking a selfie, and sharing it on social media with the hashtag #REDS4VEDS.